The aim of the present investigation is to develop a pH-dependent system for colon specific drug delivery of Budesonide by using enteric coating of Eudragit S100. Budesonide insoluble in water and unstable in gastric environment was formulated into pH-dependent tablets coated with Eudragit S100. Budesonide tablets were prepared by weight granulation method and coated with Eudragit S100 by conventional pan coating machine. All the prepared granules were evaluated for the flow properties by studied the angle of repose, compressibility index and Hauser’s ratio. The physical properties of the tablets including weight variation, friability, hardness, content uniformity and release profile in simulated gastric fluid, simulated intestinal fluid and phosphate buffer 7.4 containing 4% rat caecal and colonic contents were studied. The result shows that the 10% coating over the tablets shows 0% drug release in the gastric and intestinal medium. The 100% drug release shows after 12hrs in the phosphate buffer 7.4 containing rat caecal content 4%. The results of the present study have demonstrated that the pH-dependent tablet system is a promising vehicle for preventing rapid degradation in gastric environment and improving oral bioavailability of Budesonide for the treatment of ulcerative colitis and crohn’s disease.
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